A SPECIFIC GROWTH INHIBITION REVERSED BY PANTOTHENIC ACID

Pantothenic acid synthesis by smooth Brucella abortus.

The relationship between formation of exogenous alanine and the establishment of nonsmooth variants in originally smooth cultures of Brucella abortus strains has been clearly demonstrated (Goodlow et al., 1950). Furthermore, the addition of D-alanine to smooth cultures in synthetic medium (Gerhardt and Wilson, 1948) results in earlier establishment of nonsmooth cells (Goodlow et al., 1951). Sub...

The pantothenic acid content of coenzyme A by chick assay.

Lipmann, Kaplan, Novelli, Tuttle, and Guirard (1) reported that, whereas concentrates of the coenzyme required for acetylation (coenzyme A) showed no pantothenic acid activity by the ordinary microbiological assay, considerable amounts of p-alanine were found after acid hydrolysis. From this early observation, it was suspected that the coenzyme might contain combined pantothenic acid which was ...

Biochemical transformations as determined by competitive analogue-metabolite growth inhibitions; prevention of pantothenic acid synthesis by cysteic acid.

The study of the metabolism of cells by a method termed inhibition analysis (l-3) led to the initial proposal that the antibacterial index (4) is a function of the inhibited enzyme system which becomes the limiting factor for growth of the organism. It was further proposed that if the product of this enzyme system is supplied to the organism the analogue either becomes ineffective as a growth i...

REOVIRUS GROWTH INHIBITION BY ROTAVIRUS FOLLOWING COINFECTION

GROWTH INHIBITION OF PATHOGENS BY LACTIC ACID BACTERIA PRODUCING INHIBITORY SUBSTANCES

71 samples of milk and dairy products were collected from 18 cities throughout Iran. 93 strains of lactic acid bacteria (LAB) were isolated and assayed against four opportunistic patho gens including E. coli, proteus and klebsiella as gram-negative and S. aureus as a gram-positive organism. All indicators (organisms) were hospital strains. Among isolated bacteria, lactobacilli (37 isolates)...